Comparative e cacy of concurrent administration of a porcine circovirus type 2 (PCV2) vaccine plus a porcine reproductive and respiratory syndrome virus (PRRSV) vaccine from two commercial sources in pigs challenged with both viruses

Materials and methods: One group of pigs administered concurrently Fostera PCV and Fostera PRRS (Zoetis, Florham Park, New Jersey) and another group administered concurrently Ingelvac CircoFLEX and Ingelvac PRRS MLV (Boehringer Ingelheim Vetmedica Inc, St Joseph, Missouri) at study day -28 (21 days of age) were challenged with both viruses at study day 0 (49 days of age). Serum samples were tested for viremia by real-time polymerase chain reaction (PCR), and for antibodies by a commercial enzyme-linked immunosorbent assay and a virus neutralization test. Peripheral blood mononuclear cells were tested for interferon-γ secreting cells (IFN-γ-SC) by enzyme-linked immunospot assay. Lung and lymphoid tissues were tested for lesions and viral antigen by histopathology and immunohistochemistry.